It depends on how you're moving it. The transform.Translate() function will definitely cause problems, but changing the rigidbody.velocity directly **seems** to be safe. I can't tell you with 100% certainty but it's how I'm working and so far all is fine.
Sorry I can't give you a more certain response. Keep your eyes open for strange behavior when using functions like OnTriggerEnter or OnCollisionEnter etc.
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